Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064742 | 1.00 | BCHE (0.43) | BCHEKDM4EMAPTPKMKMT2A | |
| SCHEMBL6436095 | 1.00 | BCHE (0.43) | BCHEKDM4EMAPTPKMKMT2A | |
| Hydrochloric Acid SCHEMBL29199502 | 0.99 | BCHE (0.42) | BCHEKDM4EMAPTPKMKMT2A | |
| Hydrochloric Acid SCHEMBL11535212 | 0.99 | BCHE (0.42) | BCHEKDM4EMAPTPKMKMT2A | |
| Acetic Acid SCHEMBL10657697 | 0.92 | CYP2D6 (0.44) | BCHEKDM4EMAPTPKMKMT2A | |
| Acetic Acid SCHEMBL10657702 | 0.92 | CYP2D6 (0.44) | BCHEKDM4EMAPTPKMKMT2A | |
| Formic Acid SCHEMBL2065536 | 0.92 | BCHE (0.41) | BCHEKDM4EMAPTPKMKMT2A | |
| Acetic Acid SCHEMBL10657706 | 0.92 | CYP2D6 (0.44) | BCHEKDM4EMAPTPKMKMT2A | |
| SCHEMBL19427382 | 0.83 | PRCP (0.40) | BCHEKDM4EMAPTPKMKMT2A | |
| SCHEMBL16591499 | 0.83 | PRCP (0.40) | BCHEKDM4EMAPTPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115927230-B | Imine reductase mutant, preparation method thereof and application of imine reductase mutant in catalyzing preparation of dextromethorphan intermediate | Jindawei Biotechnology (Jiangsu) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-116265579-A | Cyclohexylamine oxidase mutant and application thereof in preparation of dextromethorphan intermediate | 复旦大学 | 2023-06-20 | — | — | CN | claimed |
| CN-115927230-A | Imine reductase mutant, preparation method thereof and application of imine reductase mutant in catalytic preparation of dextromethorphan intermediate | 金达威生物技术(江苏)有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-110007028-B | Method for detecting (S) -1- (4-methoxybenzyl) -1,2,3,4,5,6,7, 8-octahydroisoquinoline isomer | 上海葆隆生物科技有限公司 | 2021-12-10 | — | — | CN | claimed |
| CN-110628841-B | Novel method for synthesizing key intermediate of dextromethorphan through enzyme catalysis asymmetry | 中国科学院天津工业生物技术研究所 | 2021-11-23 | — | — | CN | claimed |
| CN-110628841-A | Novel method for synthesizing key intermediate of dextromethorphan through enzyme catalysis asymmetry | 中国科学院天津工业生物技术研究所 | 2019-12-31 | — | — | CN | claimed |
| CN-110007028-A | (S) detection method of -1- (4- methoxybenzyl) -1,2,3,4,5,6,7,8- octahydro isoquinolin isomers | 上海葆隆生物科技有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-108383786-A | (S) -1- (4- methoxy-benzyls) -1,2,3,4,5,6,7,8- octahydro isoquinolin the preparation methods | 启东东岳药业有限公司 | 2018-08-10 | — | — | CN | claimed |
| CN-104761494-B | A kind of preparation method of (S) or (R) 1 (4 methoxy-benzyl) 1,2,3,4,5,6,7,8 octahydro isoquinolin | 上海医药工业研究院 | 2018-01-19 | — | — | CN | claimed |
| CN-104761494-A | Preparation method of (S) or (R)-1-(4-methoxy benzyl)-1,2,3,4,5,6,7,8-octahydro isoquinoline | SHANGHAI INST PHARM INDUSTRY | 2015-07-08 | — | — | CN | claimed |
| CN-1639127-A | Process for asymmetric hydrogenation of hexahydroquinoline salts | DSM IP ASSETS BV (NL) | 2005-07-13 | — | — | CN | claimed |
| US-20050148776-A1 | Process for asymmetric hydrogenation of hexahydroquinoline salts | DSM IP ASSETS B.V. (NL) | 2005-07-07 | — | — | US | claimed |
| EP-1485357-B1 | PROCESS FOR ASYMMETRIC HYDROGENATION OF HEXAHYDROQUINOLINE SALTS | DSM IP ASSETS BV (NL) | 2005-07-06 | — | — | EP | claimed |
| EP-1485357-A1 | PROCESS FOR ASYMMETRIC HYDROGENATION OF HEXAHYDROQUINOLINE SALTS | DSM IP Assets B.V. (NL) | 2004-12-15 | — | — | EP | claimed |
| WO-2003078399-A1 | PROCESS FOR ASYMMETRIC HYDROGENATION OF HEXAHYDROQUINOLINE SALTS | DSM IP ASSETS B.V. (NL) | 2003-09-25 | — | — | WO | claimed |
| EP-0850931-B1 | Process for the preparation of optically active (R or S)-1-(4-methoxy-benzyl)-1,2,3,4,5,6,7,8-octahydro-isoquinolines | HOFFMANN LA ROCHE (CH) | 2003-05-02 | — | — | EP | claimed |
| JP-10182612-A | — | — | None | — | — | JP | disclosed |
| CN-115927230-B | Imine reductase mutant, preparation method thereof and application of imine reductase mutant in catalyzing preparation of dextromethorphan intermediate | Jindawei Biotechnology (Jiangsu) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | disclosed |
| EP-0839135-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 1-(P-METHOXYBENZYL)-1,2,3,4,5,6,7,8-OCTAHYDROISOQUINOLINE | LONZA AG (CH) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003052-A1 | PROCESS FOR PREPARING OPTICALLY ACTIVE 1-(P-METHOXYBENZYL)-1,2,3,4,5,6,7,8-OCTAHYDROISOQUINOLINE | LONZA AG (CH) | 1997-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148776-A1 | Process for asymmetric hydrogenation of hexahydroquinoline salts | HRH1, HRH4, HRH2 | BCHE 315/4885KDM4E 3360/4885MAPT 3305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.