Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438231 | 0.88 | CHRM1 (0.52) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6438606 | 0.87 | CHRM1 (0.47) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL6441749 | 0.85 | CHRM1 (0.45) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4090351 | 0.82 | CHRM1 (0.53) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4101982 | 0.80 | CHRM1 (0.55) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4095848 | 0.79 | CHRM1 (0.54) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4106718 | 0.77 | CHRM1 (0.45) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4102226 | 0.76 | CHRM1 (0.46) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL3021062 | 0.76 | CHRM1 (0.46) | CHRM1CHRM5CHRM3CHRM2CHRM4 | |
| SCHEMBL4098178 | 0.75 | CHRM1 (0.52) | CHRM1CHRM5CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461318-B9 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-12-28 | — | — | EP | claimed |
| EP-1461318-B1 | TETRAHYDROQUINOLINE ANALOGUES AS MUSCARINIC AGONISTS | ACADIA PHARM INC (US) | 2005-09-14 | — | — | EP | claimed |