Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439758 | 0.80 | BRD4 (0.45) | ALDH1A1KDM4EPOLBMAPTTDP1 | |
| SCHEMBL2783116 | 0.77 | CYP2C9 (0.54) | TPMTNR4A1KDM4EMEN1POLB | |
| SCHEMBL5158008 | 0.77 | CA12 (0.41) | TPMTNR4A1ALDH1A1KDM4EMEN1 | |
| SCHEMBL18092436 | 0.77 | CA1 (0.45) | ALDH1A1KDM4EPOLBTDP1HSD17B10 | |
| SCHEMBL480606 | 0.77 | BRD4 (0.50) | — | |
| SCHEMBL34469990 | 0.76 | TPMT (0.41) | TPMTNR4A1MEN1POLBKMT2A | |
| SCHEMBL10941908 | 0.76 | TPMT (0.43) | TPMTMEN1POLBKMT2AALOX15 | |
| SCHEMBL18348294 | 0.76 | TTR (0.40) | TPMTNR4A1ALDH1A1MEN1POLB | |
| SCHEMBL31352250 | 0.76 | TPMT (0.38) | TPMTNR4A1MEN1POLBKMT2A | |
| SCHEMBL5495438 | 0.76 | TPMT (0.38) | TPMTNR4A1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104302287-B | Indolin-2-one derivatives as protein kinase inhibitors | 安基生技新药股份有限公司 | 2017-12-26 | — | — | CN | claimed |
| CN-103601720-A | Solid salt forms of a pyrrole substituted 2-indolinone | ZOETIS P LLC | 2014-02-26 | — | — | CN | claimed |
| CN-101287724-B | Solid salt forms of pyrrole substituted 2-indolones | PFIZER PROD INC | 2013-11-06 | — | — | CN | claimed |
| CN-101333215-B | Synthesis method of sunitinib alkali | NANJING UNIVERSITY OF TECHNOLOGY | 2011-01-12 | — | — | CN | claimed |
| CN-101033226-B | 1-furylmethyl-3-substituted indolin-2-one derivative | UNIV FUDAN | 2010-05-19 | — | — | CN | claimed |
| CN-100500213-C | Anti-tumour medicinal composition containing blood vessel inhibitor | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2009-06-17 | — | — | CN | claimed |
| CN-101333215-A | Synthesis method of sunitinib alkali | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2008-12-31 | — | — | CN | claimed |
| CN-101033226-A | 1-furylmethyl-3-substituted indolin-2-one derivative | UNIV FUDAN (CN) | 2007-09-12 | — | — | CN | claimed |
| CN-101020057-A | Composition for treating solid tumor | JINAN SHUAIHUA MEDICINE SCI TE (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-101019831-A | Slow releasing anticancer prepn containing vasoinhibitor | JINAN SHUAIHUA MEDICINE SCI TE (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-1733300-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733302-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733304-A | Anticancer medicine composition containing blood vessel inhibitor | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733306-A | Anticancer implantation agent containing blood vessel inhibitor and guanine similarities | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733301-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733305-A | Anticancer implantation agent | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1733303-A | Anticancer implantation agent containing blood vessel inhibitor | KONG QINGZHONG (CN) | 2006-02-15 | — | — | CN | claimed |
| CN-1686546-A | Anti entity tumour medicinal composition containing blood vessel inhibitor | SHANDONG LANJIN BIOLOG ENGINEE (CN) | 2005-10-26 | — | — | CN | claimed |
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | claimed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | claimed |