Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14202975 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| SCHEMBL14203005 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| SCHEMBL8284213 | 1.00 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| Hydrochloric Acid SCHEMBL5429601 | 0.99 | SLC6A2 (0.98) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| Hydrochloric Acid SCHEMBL5038401 | 0.99 | SLC6A2 (0.98) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| Hydrochloric Acid SCHEMBL5038398 | 0.99 | SLC6A2 (0.98) | SLC6A2SLC6A4SLC6A3CYP2D6CHRNB2 | |
| SCHEMBL5045862 | 0.92 | SLC6A2 (0.85) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5042283 | 0.92 | SLC6A2 (0.85) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5045971 | 0.90 | SLC6A2 (0.82) | SLC6A2SLC6A4CYP2D6KCNH2 | |
| SCHEMBL5048152 | 0.90 | SLC6A2 (0.80) | SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534694-A1 | ARYL AND HETEROARYL MORPHOLINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2005021095-A2 | TREATMENT OF STUTTERING AND OTHER COMMUNICATION DISORDERS WITH NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |
| WO-2004018441-A1 | ARYL AND HETEROARYL MORPHOLINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2004-03-04 | — | — | WO | disclosed |