Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ADH1B | P00325 | 1/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
| ▸ | ADH7 | P40394 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319986 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL20155192 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL8394528 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL4103322 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL14448413 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL19359628 | 0.79 | EPHX1 (0.50) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL5211292 | 0.79 | EPHX1 (0.61) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL31284220 | 0.77 | EPHX1 (0.48) | EPHX1CA12CA1CA2MMP1 | |
| Hydrochloric Acid SCHEMBL28129388 | 0.77 | CYP2D6 (0.48) | EPHX1CA12CA1CA2MMP1 | |
| SCHEMBL23717992 | 0.76 | EPHX1 (0.47) | EPHX1CA12CA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | claimed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | claimed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | claimed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | claimed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | claimed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | claimed |
| US-6936622-B2 | 6-phenylbenzonaphthyridines | ALTANA PHARMA AG (DE) | 2005-08-30 | — | — | US | disclosed |
| EP-1377574-B1 | 6-PHENYLBENZONAPHTHYRIDINES | BYK GULDEN LOMBERG CHEM FAB (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | TAKEDA GMBH (DE) | 2004-05-20 | — | — | US | disclosed |
| EP-1377574-A1 | 6-PHENYLBENZONAPHTHYRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002066476-A9 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2003-10-30 | — | — | WO | disclosed |
| WO-2002066476-A1 | 6-PHENYLBENZONAPHTHYRIDINES | ALTANA PHARMA AG (DE) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097537-A1 | 6-phenylbenzonaphthyridines | PDE3A, PDE4A, PDE3B | EPHX1 2106/4885CA12 4206/4885CA1 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.