SCHEMBL643947

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL643650	0.92	GCK (0.52)	GCKHIF1AFFAR4EZH2ALDH1A1
	SCHEMBL2645431	0.85	GCK (0.58)	GCKHIF1AFFAR4EZH2LPAR1
	SCHEMBL644377	0.85	GCK (0.52)	GCKHIF1AFFAR4EZH2LPAR1
	SCHEMBL2644082	0.84	GCK (0.53)	GCKHIF1AFFAR4EZH2LPAR1
	SCHEMBL2643938	0.83	GCK (0.59)	GCKFFAR4EZH2LPAR1LPAR5
	SCHEMBL643429	0.83	GCK (0.76)	GCK
	SCHEMBL2644620	0.82	GCK (0.47)	GCKFFAR4EZH2KDM4EALDH1A1
	SCHEMBL2644556	0.82	GCK (0.69)	GCKKDM4EALDH1A1HSD17B10GLA
	SCHEMBL2644128	0.82	GCK (0.71)	GCKKDM4EALDH1A1HSD17B10GLA
	SCHEMBL2644107	0.82	GCK (0.56)	GCKFFAR4EZH2LPAR1LPAR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.