Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355227 | 0.85 | TLR7 (0.51) | TLR7TLR8LMNATP53PDE4A | |
| SCHEMBL5362485 | 0.82 | TLR7 (0.52) | TLR7TLR8LMNATP53PDE4A | |
| SCHEMBL5349584 | 0.75 | TLR7 (0.52) | TLR7TLR8TP53GAAHTT | |
| SCHEMBL483645 | 0.74 | TLR7 (0.76) | TLR7TLR8 | |
| SCHEMBL31006040 | 0.74 | TLR7 (0.76) | TLR7TLR8 | |
| SCHEMBL5362468 | 0.73 | TLR7 (0.41) | TLR7TLR8SMN1; SMN2 | |
| SCHEMBL5360565 | 0.73 | TLR7 (0.77) | TLR7TLR8 | |
| SCHEMBL5357057 | 0.73 | TLR7 (0.53) | TLR7TLR8PDE4APDE4BPDE4C | |
| SCHEMBL1896335 | 0.72 | TLR7 (0.47) | TLR7TLR8ALDH1A1PDE4APDE4B | |
| SCHEMBL4792955 | 0.72 | TLR7 (0.45) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1541572-A1 | Thioether substituted imidazoquinolines | 3M Innovative Properties Company (US) | 2005-06-15 | — | — | EP | disclosed |