Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16672742 | 0.80 | SMN1; SMN2 (0.51) | MEN1KMT2ATSHRLMNASMN1; SMN2 | |
| SCHEMBL1744701 | 0.79 | CA12 (0.47) | KMT2ATDP1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL30754254 | 0.78 | TSHR (0.46) | MEN1KMT2ATDP1MAPTTSHR | |
| SCHEMBL14797820 | 0.73 | PSEN1 (0.41) | AKR1C3AKR1C2BCHEACHEMEN1 | |
| SCHEMBL14797835 | 0.73 | PSEN1 (0.41) | AKR1C3AKR1C2BCHEACHEMEN1 | |
| SCHEMBL363983 | 0.73 | TSHR (0.48) | MEN1KMT2ATDP1TSHRLMNA | |
| SCHEMBL6438968 | 0.72 | CYP4F2 (0.49) | MAPTSMN1; SMN2 | |
| SCHEMBL27467385 | 0.71 | HDAC8 (0.47) | AKR1C3AKR1C2BCHEACHEHDAC8 | |
| SCHEMBL490708 | 0.71 | CA12 (0.54) | KMT2ATDP1MAPTSMN1; SMN2 | |
| SCHEMBL18745644 | 0.71 | SMN1; SMN2 (0.45) | AKR1C3AKR1C2BCHEACHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511740-A1 | PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003101978-A1 | PHENYL-THIOPHENE TYPE VITAMIN D RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-12-11 | — | — | WO | disclosed |