Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6030979 | 0.98 | HRH1 (0.65) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL6030410 | 0.81 | HRH1 (0.44) | HRH1PARP1 | |
| Vapitadine SCHEMBL29379463 | 0.79 | HRH1 (1.00) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| Vapitadine SCHEMBL6440903 | 0.79 | HRH1 (1.00) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| Vapitadine SCHEMBL3463472 | 0.78 | HRH1 (1.00) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL6031354 | 0.75 | HRH1 (0.51) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| Hydrochloric Acid SCHEMBL6440622 | 0.74 | HRH1 (0.73) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL6031770 | 0.71 | HRH1 (0.47) | HRH1HTR2A | |
| SCHEMBL6030956 | 0.70 | HRH1 (0.66) | HRH1HTR2AHTR2CDRD2SLC6A2 | |
| SCHEMBL6031761 | 0.70 | HRH1 (0.49) | HRH1HTR2AHTR2CDRD2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144411-B1 | ANTIHISTAMINIC SPIRO COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2005-04-27 | — | — | EP | claimed |