Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyl Fumarate SCHEMBL30387534 | 1.00 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL31439648 | 1.00 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1902730 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL9435698 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL5016627 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1905731 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1904374 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1903287 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL20594713 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 | |
| Ethyl Fumarate SCHEMBL1904369 | 0.95 | HCAR2 (0.61) | HCAR2MAPTATMNPSR1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858750-B2 | Use of fumaric acid derivatives for treating mitochondrial diseases | FUMAPHARM AG (CH) | 2005-02-22 | — | — | US | disclosed |
| US-6277882-B1 | SKIN DISORDERS | FUMAPHARM AG (CH) | 2001-08-21 | — | — | US | disclosed |