Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.37 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.37 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6439613 | 0.89 | RHOA (0.42) | PROKR1MEN1KMT2A | |
| SCHEMBL6442326 | 0.84 | TACR1 (0.44) | HSD11B1SLC18A3NPC1RAB9A | |
| SCHEMBL6442330 | 0.84 | TACR1 (0.44) | HSD11B1SLC18A3NPC1RAB9A | |
| SCHEMBL5802899 | 0.80 | RHOA (0.54) | PROKR1MEN1KMT2A | |
| SCHEMBL5802902 | 0.80 | RHOA (0.54) | PROKR1MEN1KMT2A | |
| SCHEMBL5803870 | 0.79 | HIF1A (0.47) | PROKR1 | |
| SCHEMBL6442171 | 0.79 | KDM1A (0.46) | SLC18A3KDM1ANPC1RAB9A | |
| SCHEMBL5918091 | 0.79 | TACR1 (0.43) | PROKR1 | |
| SCHEMBL6442173 | 0.79 | KDM1A (0.46) | SLC18A3KDM1ANPC1RAB9A | |
| SCHEMBL5800732 | 0.79 | TACR1 (0.49) | KDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360184-B1 | PIPERIDINE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-03-30 | — | — | EP | disclosed |