Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443177 | 0.97 | HRH3 (0.70) | HRH3MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6444083 | 0.97 | HRH3 (0.70) | HRH3MAPTCYP1A2L3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL8490153 | 0.97 | HRH3 (0.62) | HRH3MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL2747040 | 0.97 | HRH3 (0.70) | HRH3MAPTCYP1A2L3MBTL1MAPK1 | |
| SCHEMBL6442159 | 0.97 | HRH3 (0.70) | HRH3MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL6444053 | 0.95 | HRH3 (0.75) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL6443349 | 0.95 | HRH3 (0.75) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL6447947 | 0.95 | HRH3 (0.75) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7101066 | 0.95 | HRH3 (0.67) | HRH3MAPTCYP1A2L3MBTL1MAPK1 | |
| SCHEMBL6442289 | 0.95 | HRH3 (0.75) | HRH3MAPTCYP1A2MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107698539-A | The preparation method of Buflomedil Hydrochloride | 陕西启源科技发展有限责任公司 | 2018-02-16 | — | — | CN | claimed |
| CN-107698539-A | The preparation method of Buflomedil Hydrochloride | 陕西启源科技发展有限责任公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-101486701-B | Chromanone compound and analogue and medical application thereof | UNIV SHENYANG PHARMACEUTICAL | 2013-06-19 | — | — | CN | disclosed |
| US-6858679-B2 | Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions | FMC CORPORATION (US) | 2005-02-22 | — | — | US | disclosed |
| US-20030153693-A1 | Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions | QUIRK RODERIC PAUL (US) | 2003-08-14 | — | — | US | disclosed |
| US-6605564-B1 | Anionic polymerization initiators and salt additives selected from sodium chloride, sodium iodide, potassium chloride, potassium t-butoxide, for increasing the efficiency of reactions between living polymer anions and electrophiles | FMC CORPORATION | 2003-08-12 | — | — | US | disclosed |
| US-6545103-B2 | Living polymers | FMC CORPORATION | 2003-04-08 | — | — | US | disclosed |
| US-20020010082-A1 | Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions | FMC CORPORATION | 2002-01-24 | — | — | US | disclosed |
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| US-4357280-A | Use of tertiary phosphines in photographic silver dye bleach materials | CIBA-GEIGY AG (CH) | 1982-11-02 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |
| US-4138256-A | Method of processing photographic silver dye bleach materials | CIBA-GEIGY AG (CH) | 1979-02-06 | — | — | US | disclosed |
| US-3953425-A | Azepine indanyl and tetralin butyrophenones | THE UPJOHN COMPANY (US) | 1976-04-27 | — | — | US | disclosed |