Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.73 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.61 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27206277 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL27206278 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL5408217 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL30866218 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4665021 | 0.83 | DPP4 (0.72) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL8282472 | 0.78 | DPP4 (0.55) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL8281186 | 0.74 | DPP4 (0.50) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL6758476 | 0.74 | DPP4 (0.80) | DPP4DPP7 | |
| SCHEMBL875040 | 0.74 | CA1 (0.46) | DPP4 | |
| SCHEMBL20873266 | 0.74 | CA1 (0.46) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1604662-A1 | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft (DE) | 2005-12-14 | — | — | EP | disclosed |