Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319614 | 0.89 | GAA (0.62) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL8320971 | 0.89 | KDM4E (0.59) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL30310515 | 0.88 | KDM4E (0.57) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL20604977 | 0.88 | KDM4E (0.57) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL8324363 | 0.88 | GAA (0.60) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL8322794 | 0.88 | KDM4E (0.57) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL5106377 | 0.88 | KDM4E (0.57) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL3602542 | 0.85 | KDM4E (1.00) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL29824959 | 0.85 | KDM4E (1.00) | KDM4EHPGDGAAGLAKMT2A | |
| SCHEMBL10510170 | 0.82 | GLA (0.54) | KDM4EHPGDGAAGLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108630-A1 | Hedgehog Pathway Antagonists and Methods of Use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| US-8119640-B2 | Hedgehog pathway antagonists methods of use | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-02-21 | — | — | US | disclosed |
| US-20110015201-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-20 | — | — | US | disclosed |
| US-5866594-A | Indole-2-carboxylate derivatives and fungicidal compositions for agricultural or horticultural use containing the derivatives as active component | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0791582-A1 | INDOLE-2-CARBOXYLIC ESTER DERIVATIVES AND AGRICULTURAL AND HORTICULTURAL BACTERIOCIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015201-A1 | HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE | SHH, GLI1, SMO | KDM4E 1642/4885HPGD 3250/4885GAA 2837/4885 |
| US-20120108630-A1 | Hedgehog Pathway Antagonists and Methods of Use | SHH, GLI1, SMO | KDM4E 1642/4885HPGD 3250/4885GAA 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.