Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29189078 | 0.93 | BCL9 (0.59) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL6577540 | 0.90 | BCL9 (0.74) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL15548469 | 0.89 | BCL9 (0.56) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL29189081 | 0.88 | BCL9 (0.54) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL5762656 | 0.87 | BCL9 (0.60) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL278663 | 0.87 | BCL9 (0.62) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL6395955 | 0.87 | BCL9 (0.60) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL4644859 | 0.86 | BCL9 (0.58) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL31331481 | 0.86 | BCL9 (0.59) | BCL9CTNNB1HTR2AMAPTGAA | |
| SCHEMBL31629546 | 0.86 | BCL9 (0.59) | BCL9CTNNB1HTR2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897236-B1 | Aminobenzophenones as inhibitors of IL-1β and TNF-α | LEO PHARMACEUTICAL PRODUCTS, LTD. (DK) | 2005-05-24 | — | — | US | disclosed |
| EP-1202959-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| EP-1202959-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1-BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005749-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |