SCHEMBL644481

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2643574	0.90	GCK (0.50)	GCKRAB9ASMN1; SMN2HPGDALDH1A1
	SCHEMBL643613	0.88	GCK (0.53)	GCKHPGDALDH1A1GAAKDM4E
	SCHEMBL643595	0.86	GCK (0.40)	GCKLMNAMAPTNPSR1TSHR
	SCHEMBL643310	0.85	GCK (0.55)	GCKLMNAMAPTNPSR1TSHR
	SCHEMBL643092	0.85	GCK (0.46)	GCKLMNAMAPTNPSR1TSHR
	SCHEMBL642887	0.84	GCK (0.41)	GCKLMNAMAPTNPSR1TSHR
	SCHEMBL643676	0.83	GCK (0.38)	GCKLMNAMAPTNPSR1TSHR
	SCHEMBL643655	0.82	GCK (0.76)	GCKKCNH2
	SCHEMBL643908	0.81	GCK (0.72)	GCKHPGDGAA
	SCHEMBL642456	0.79	GCK (0.52)	GCKHPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.