Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315291 | 0.94 | GSK3B (0.47) | GSK3BCYP2D6MAPTPRKACAROCK1 | |
| SCHEMBL315955 | 0.93 | GSK3B (0.43) | GSK3BCYP2D6MAPTALDH1A1CYP1A2 | |
| SCHEMBL316072 | 0.86 | GSK3B (0.44) | GSK3BCYP2D6MAPTL3MBTL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL315968 | 0.85 | GSK3B (0.45) | GSK3BCYP2D6MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL315314 | 0.84 | GSK3B (0.46) | GSK3BCYP2D6TDP1ALDH1A1CYP1A2 | |
| SCHEMBL315639 | 0.84 | GSK3B (0.46) | GSK3BCYP2D6TDP1ALDH1A1CYP1A2 | |
| SCHEMBL4865807 | 0.84 | GSK3B (0.45) | GSK3BCYP2D6MAPTMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL315474 | 0.83 | GSK3B (0.46) | GSK3BCYP2D6TDP1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL315489 | 0.83 | GSK3B (0.46) | GSK3BCYP2D6TDP1ALDH1A1CYP1A2 | |
| SCHEMBL317015 | 0.82 | GSK3B (0.49) | GSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608654-A2 | 8-SUBSTITUTED-6, 7, 8,9-TETRAHY9DROPYRIMIDO (1,2- a) PYRIMIDIN-4-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2005-12-28 | — | — | EP | claimed |
| WO-2004082577-A2 | 8-SUBSTITUTED-6, 7, 8, 9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2004-09-30 | — | — | WO | claimed |