Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.48 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378159 | 0.92 | KDR (0.57) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL377912 | 0.92 | KDR (0.47) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL6444237 | 0.87 | KDR (0.65) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL7830884 | 0.87 | KDR (0.47) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL7827254 | 0.87 | KDR (0.64) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL5352399 | 0.86 | KDR (0.68) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL378513 | 0.85 | KDR (0.45) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL378418 | 0.85 | KDR (0.41) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL3071804 | 0.85 | KDR (0.59) | KDRPDGFRBFLT1ABL1FYN | |
| SCHEMBL3091110 | 0.84 | KDR (0.57) | KDRPDGFRBFLT1ABL1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545519-A1 | COMBINATION THERAPY FOR HYPERPROLIFERATIVE DISEASES | Pfizer Products Inc. (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004017964-A1 | COMBINATION THERAPY FOR HYPERPROLIFERATIVE DISEASES | PFIZER PRODUCTS INC. (US) | 2004-03-04 | — | — | WO | claimed |
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | claimed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1084114-B1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1084114-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062890-A1 | ISOTHIAZOLE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |