Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 12/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | PRCP | P42785 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316432 | 0.97 | PIK3CA (0.44) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL315487 | 0.96 | GSK3B (0.45) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL316247 | 0.90 | GSK3B (0.48) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| Hydrochloric Acid SCHEMBL316027 | 0.90 | GSK3B (0.47) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL316032 | 0.89 | GSK3B (0.44) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL316559 | 0.89 | GSK3B (0.46) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL315660 | 0.87 | GSK3B (0.42) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL315353 | 0.87 | GSK3B (0.44) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL314664 | 0.86 | GSK3B (0.43) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 | |
| SCHEMBL315672 | 0.85 | SLC18A3 (0.43) | PIK3CAPIK3C3GSK3BPIK3R1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608654-A2 | 8-SUBSTITUTED-6, 7, 8,9-TETRAHY9DROPYRIMIDO (1,2- a) PYRIMIDIN-4-ONE DERIVATIVES | Sanofi-Aventis (FR) | 2005-12-28 | — | — | EP | claimed |
| WO-2004082577-A2 | 8-SUBSTITUTED-6, 7, 8, 9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2004-09-30 | — | — | WO | claimed |