Fluoride

Fluoride

SCHEMBL6446007

F.O=C(O)c1cccc(Cl)c1Cl

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.95
ALDH1A1 P00352 3/20 0.64
ERCC5 P28715 1/20 0.56
FEN1 P39748 1/20 0.56
P2RX7 Q99572 2/20 0.50
ALOX15 P16050 1/20 0.50
CYP2C9 P11712 2/20 0.49
PBRM1 Q86U86 1/20 0.49
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
NOTUM Q6P988 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 2/20 0.47
JAK2 O60674 1/20 0.47
TAS1R3 Q7RTX0 1/20 0.47
TAS1R1 Q7RTX1 1/20 0.47
TAS1R2 Q8TE23 1/20 0.47
USP2 O75604 1/20 0.47
MT-CO2 P00403 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL27648455 1.00 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
SCHEMBL97298 0.98 TSHR (1.00) TSHRALDH1A1ERCC5FEN1P2RX7
SCHEMBL29904615 0.98 TSHR (1.00) TSHRALDH1A1ERCC5FEN1P2RX7
Ammonia Solution, Strong SCHEMBL264005 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
SCHEMBL11800294 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
SCHEMBL2048711 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
Hydrochloric Acid SCHEMBL11032955 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
SCHEMBL8616119 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
Ammonia Solution, Strong SCHEMBL29582984 0.95 TSHR (0.95) TSHRALDH1A1ERCC5FEN1P2RX7
Hydrochloric Acid SCHEMBL11678742 0.93 TSHR (0.91) TSHRALDH1A1ERCC5FEN1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1233010-B1 Method for production of organic fluorine compound NIPPON CATALYTIC CHEM IND (JP) 2005-06-15 EP disclosed
EP-0899256-B1 Method for production of organic fluorine compound NIPPON CATALYTIC CHEM IND (JP) 2003-08-06 EP disclosed
EP-1233010-A1 Method for production of organic fluorine compound Nippon Shokubai Co., Ltd. (JP) 2002-08-21 EP disclosed
US-6392084-B1 FLUORINATION OF AN ORGANO(BROMINE OR CHLORIDE) COMPOUND IN BENZONITRILE SOLVENT NIPPON SHOKUBAI CO., LTD. (JP) 2002-05-21 US disclosed
EP-0899256-A2 Method for production of organic fluorine compound NIPPON SHOKUBAI CO., LTD. (JP) 1999-03-03 EP disclosed