Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 2/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6446766 | 1.00 | PPM1B (0.32) | PPM1BPTPN1PPP1CCGRM2GRM3 | |
| SCHEMBL6447097 | 0.83 | KAT2A (0.33) | PPM1BPTPN1PPP1CCGRM8 | |
| SCHEMBL6447098 | 0.83 | KAT2A (0.33) | PPM1BPTPN1PPP1CCGRM8 | |
| SCHEMBL31124089 | 0.75 | POLB (0.39) | PPM1BPTPN1PPP1CCGRM2GRM3 | |
| SCHEMBL32677595 | 0.75 | POLB (0.39) | PPM1BPTPN1PPP1CCGRM2GRM3 | |
| SCHEMBL12763447 | 0.72 | POLB (0.38) | PPM1BPTPN1PPP1CCGRM2GRM3 | |
| SCHEMBL11761139 | 0.72 | SUCNR1 (0.35) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL12094374 | 0.72 | SUCNR1 (0.35) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL20143298 | 0.72 | SUCNR1 (0.35) | GRM2GRM3GRM8POLBCTDSP1 | |
| SCHEMBL7143232 | 0.71 | GRM2 (0.42) | GRM2GRM3GRM8POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189874-B1 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | LILLY SA (ES) | 2005-01-26 | — | — | EP | disclosed |
| US-6504052-B1 | 2-carboxycyclopropyl glycine derivatives, used as agonists of glutamate receptors for prophylaxis of psychological and nervous system disorders; anxiolytics; antidepressants; drug abuse; anticonvulsant, analgesic and antiemetic agents | ELI LILLY AND COMPANY | 2003-01-07 | — | — | US | disclosed |