Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.34 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654038 | 0.89 | KMT2A (0.47) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL11447657 | 0.88 | KDM4E (0.42) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL11450595 | 0.85 | KMT2A (0.44) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL4055640 | 0.85 | KMT2A (0.44) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL10461262 | 0.79 | KMT2A (0.50) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL1057982 | 0.79 | SMN1; SMN2 (0.35) | L3MBTL1KDM4EHPGDMAPTGAA | |
| SCHEMBL21899044 | 0.79 | KMT2A (0.50) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL11021157 | 0.77 | KMT2A (0.48) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL10358952 | 0.77 | KMT2A (0.53) | KMT2AL3MBTL1KDM4EHPGDHTR1A | |
| SCHEMBL9324460 | 0.77 | MAPT (0.45) | L3MBTL1KDM4EHPGDMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| EP-0445026-B1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1994-01-26 | — | — | EP | disclosed |
| US-5229398-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5229399-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5192775-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-03-09 | — | — | US | disclosed |
| EP-0445026-A1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-09-04 | — | — | EP | disclosed |
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |
| US-4810713-A | Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0235463-A2 | N-substituted-arylalkyl and arylalkylene piperidines as cardiovascular antihistaminic and antisecretory agents | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1987-09-09 | — | — | EP | disclosed |
| EP-0209763-A1 | Salts of morpholiniocarboxylic esters and morpholinioalkyl-phenylethers, processes for their preparation, and their use as fungicides | Institut für Pflanzenschutzforschung Kleinmachnow der A.d.L. der DDR (DD) | 1987-01-28 | — | — | EP | disclosed |
| US-4027028-A | HYPOTENSIVE AGENTS | SCIENCE UNION ET CIE (FR) | 1977-05-31 | — | — | US | disclosed |