Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | GHSR | Q92847 | 5/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CPS1 | P31327 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447630 | 1.00 | CYP2D6 (0.58) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6443731 | 0.90 | CYP2C19 (0.63) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6443726 | 0.90 | CYP2C19 (0.63) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6441267 | 0.89 | CYP2C19 (0.62) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6441264 | 0.89 | CYP2C19 (0.62) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6441531 | 0.89 | CYP2C19 (0.51) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6441534 | 0.89 | CYP2C19 (0.51) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL7661695 | 0.87 | CYP2C19 (0.62) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR | |
| SCHEMBL6449947 | 0.87 | CYP2C9 (0.50) | CYP2D6CYP2C19CYP2C9CYP3A4L3MBTL1 | |
| SCHEMBL6443879 | 0.86 | CYP2C19 (0.58) | CYP2D6CYP2C19CYP2C9CYP3A4GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002004440-A9 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-11-03 | — | — | WO | claimed |
| EP-1299382-B1 | COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED INDOLEOXOACETIC PIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-09-21 | — | — | EP | claimed |
| US-6573262-B2 | Compounds for treating mammals infected with HIV virus | BRISTOL-MYERS SQIBB COMPANY | 2003-06-03 | — | — | US | claimed |
| US-20030069245-A1 | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2003-04-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069245-A1 | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives | IDO1, IDO2, ITPA | CYP2D6 831/4885CYP2C19 1624/4885CYP2C9 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.