Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 16/20 | 0.47 |
| ▸ | KDR | P35968 | 10/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3194161 | 1.00 | SRC (0.47) | SRCKDREGFRBMPR1BBMPR1A | |
| SCHEMBL3196521 | 0.93 | SRC (0.51) | SRCKDREGFR | |
| SCHEMBL3196290 | 0.81 | SRC (0.67) | SRCKDREGFRBMPR1BBMPR1A | |
| SCHEMBL4031150 | 0.81 | SRC (0.50) | SRCKDREGFR | |
| Trifluoroacetic Acid SCHEMBL6829065 | 0.80 | SRC (0.57) | SRCKDREGFR | |
| SCHEMBL3192110 | 0.79 | SRC (0.64) | SRCKDREGFR | |
| SCHEMBL3184784 | 0.79 | SRC (0.62) | SRCKDREGFRBMPR1BBMPR1A | |
| Trifluoroacetic Acid SCHEMBL6823695 | 0.78 | SRC (0.54) | SRCKDREGFR | |
| SCHEMBL3205180 | 0.76 | SRC (0.55) | SRCKDREGFR | |
| Azd-0424 SCHEMBL3202072 | 0.76 | SRC (0.73) | SRCKDREGFRBMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | Astrazeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043472-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |