Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 2/20 | 0.42 |
| ▸ | RHOA | P61586 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3890983 | 1.00 | KCNH2 (0.60) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL3890990 | 1.00 | KCNH2 (0.60) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| Trifluoroacetic Acid SCHEMBL6456222 | 0.95 | KCNH2 (0.56) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| Trifluoroacetic Acid SCHEMBL6465124 | 0.95 | KCNH2 (0.56) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL30864972 | 0.93 | KCNH2 (0.67) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL3890222 | 0.89 | KCNH2 (0.60) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL3890220 | 0.89 | KCNH2 (0.60) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL3890171 | 0.87 | KCNH2 (0.61) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL3890167 | 0.87 | KCNH2 (0.61) | KCNH2CACNA1IMCHR1HTR1AADRA2A | |
| SCHEMBL13568433 | 0.86 | KCNH2 (0.62) | KCNH2CACNA1IMCHR1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | KCNH2 1870/4885CACNA1I 1174/4885MCHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.