Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.59 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57542 | 0.86 | KDM4E (0.69) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL1613027 | 0.84 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL11506441 | 0.84 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL31715997 | 0.84 | KDM4E (0.67) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL13209738 | 0.83 | KDM4E (0.69) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL27388864 | 0.81 | MAPT (0.63) | KDM4EHTTUSP2MAPTALDH1A1 | |
| SCHEMBL9574610 | 0.81 | NCOA1 (0.60) | NCOA1NCOA3 | |
| SCHEMBL28691005 | 0.81 | NCOA1 (0.60) | KDM4EHTTPOLBNCOA1NCOA3 | |
| SCHEMBL5202032 | 0.81 | NCOA1 (0.65) | KDM4EHTTALDH1A1POLBNCOA1 | |
| SCHEMBL5781546 | 0.80 | KDM4E (0.61) | KDM4EHTTUSP2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590660-A | Quinoline carboxamide compound, preparation method thereof and application of quinoline carboxamide compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590660-B | Quinoline carboxamide compound, preparation method thereof and application of quinoline carboxamide compound in resisting enterovirus 71 | 武汉大学 | 2021-02-19 | — | — | CN | disclosed |
| CN-110590660-B | Quinoline carboxamide compound, preparation method thereof and application of quinoline carboxamide compound in resisting enterovirus 71 | 武汉大学 | 2021-02-19 | — | — | CN | disclosed |
| CN-110590660-A | Quinoline carboxamide compound, preparation method thereof and application of quinoline carboxamide compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | disclosed |
| CN-110590660-A | Quinoline carboxamide compound, preparation method thereof and application of quinoline carboxamide compound in resisting enterovirus 71 | 武汉大学 | 2019-12-20 | — | — | CN | disclosed |
| WO-2007008657-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-01-18 | — | — | WO | disclosed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
| CN-1067684-C | Imidazo [1,5-1] quinolines for treatment of anxiety and sleep disorders | PHAMACIA UPJOHN CO (US) | 2001-06-27 | — | — | CN | disclosed |
| CN-1135753-A | Imidazo [1, 5-a ] quinolines for the treatment of anxiety and sleep disorders | UPJOHN CO (US) | 1996-11-13 | — | — | CN | disclosed |
| EP-0123146-B1 | COMPOUND WITH ANTIINFLAMMATORY ACTIVITY, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREFROM | CHIESI FARMACEUTICI S.p.A. (IT) | 1990-05-23 | — | — | EP | disclosed |
| US-4839366-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC | CHIESI FARMACEUTICI S.P.A. (IT) | 1989-06-13 | — | — | US | disclosed |
| US-4767698-A | PHOTOSTABILITY, HEAT RESISTANCE | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1988-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | KDM4E 1190/4885HTT 500/4885USP2 3448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.