Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.45 |
| ▸ | HTR2B | P41595 | 6/20 | 0.45 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 4/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6460081 | 1.00 | MCHR1 (0.47) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Trifluoroacetic Acid SCHEMBL6459930 | 0.89 | MCHR1 (0.52) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6456780 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6455816 | 0.80 | MCHR1 (0.60) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6457080 | 0.78 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6457088 | 0.78 | MCHR1 (0.59) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458491 | 0.76 | MCHR1 (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6458480 | 0.76 | MCHR1 (0.50) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6866358 | 0.76 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BHRH1ADRA1A | |
| SCHEMBL6879442 | 0.76 | MCHR1 (0.76) | MCHR1ADRA2AHTR2BHRH1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | MCHR1 2/4885ADRA2A 117/4885HTR2B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.