Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 2/20 | 0.64 |
| ▸ | EIF2AK3 | Q9NZJ5 | 6/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14183076 | 1.00 | TEK (0.64) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL30527006 | 1.00 | TEK (0.64) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6461797 | 1.00 | TEK (0.64) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6460184 | 0.94 | TEK (0.67) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6465003 | 0.94 | TEK (0.63) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6463702 | 0.94 | TEK (0.62) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6465261 | 0.92 | TEK (0.66) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6462812 | 0.91 | TEK (0.70) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL2074338 | 0.90 | EIF2AK3 (0.53) | TEKEIF2AK3EGFRERBB2ERBB4 | |
| SCHEMBL6460003 | 0.90 | TEK (0.63) | TEKEIF2AK3EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | ABBOTT LABORATORIES | 2005-01-13 | — | — | US | disclosed |
| US-6713474-B2 | SERINE-THREONINE AND TYROSINE KINASE INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2004-03-30 | — | — | US | disclosed |
| US-20030153752-A1 | Pyrrolopyrimidines as therapeutic agents | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050008640-A1 | Method of treating transplant rejection | LCK, ZAP70, FYN | TEK 1465/4885EIF2AK3 3756/4885EGFR 818/4885 |
| US-20030153752-A1 | Pyrrolopyrimidines as therapeutic agents | FLT1, FLT4, TFPI | TEK 22/4885EIF2AK3 928/4885EGFR 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.