Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 9/20 | 0.64 |
| ▸ | HTR2B | P41595 | 6/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527549 | 1.00 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6455670 | 0.96 | MCHR1 (0.60) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6462420 | 0.89 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6462425 | 0.89 | MCHR1 (0.64) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6456498 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6456503 | 0.88 | MCHR1 (0.65) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6875037 | 0.85 | MCHR1 (0.60) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| Trifluoroacetic Acid SCHEMBL6458228 | 0.85 | MCHR1 (0.60) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6463252 | 0.85 | MCHR1 (0.78) | MCHR1ADRA2AHTR2BADRA1AHTR1A | |
| SCHEMBL6463257 | 0.85 | MCHR1 (0.78) | MCHR1ADRA2AHTR2BADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | claimed |
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | claimed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | claimed |
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | TAISHO PHARMACEUTICAL CO., LTD. | 2005-09-08 | — | — | US | disclosed |
| US-6891005-B2 | Bridged metal complexes for gas phase polymerizations | BP CHEMICALS LIMITED (GB) | 2005-05-10 | — | — | US | disclosed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |
| US-20030199650-A1 | Bridged metal complexes for gas phase polymerizations | BP CHEMICALS LIMITED | 2003-10-23 | — | — | US | disclosed |
| US-6376406-B1 | COORDINATION POLYMERIZATION CATALYSTS FOR ALPHA-OLEFINS | THE DOW CHEMICAL COMPANY | 2002-04-23 | — | — | US | disclosed |
| US-6284905-B1 | GROUP 4 TRANSITION METAL COMPLEX CONTAINING A BORON OR ALUMINUM BRIDGING GROUP CONTAINING A NITROGEN CONTAINING ELECTRON DONATING GROUP, ESPECIALLY AN AMIDO GROUP; OLEFIN SOLUTION OR SLURRY POLYMERIZATION CATALYSTS | THE DOW CHEMICAL COMPANY | 2001-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197350-A1 | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof | HCRTR2, MCHR1, MCHR2 | MCHR1 2/4885ADRA2A 117/4885HTR2B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.