Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6464066 | 1.00 | DYRK1A (0.36) | DYRK1AHTR2CHTR2AHTR2BSLC6A2 | |
| SCHEMBL6464061 | 0.80 | HTR2C (0.54) | HTR2CHTR2AHTR2BDRD3 | |
| SCHEMBL6468100 | 0.78 | HTR2C (0.56) | DYRK1AHTR2CHTR2AHTR2BSLC6A2 | |
| SCHEMBL6468095 | 0.78 | HTR2C (0.56) | DYRK1AHTR2CHTR2AHTR2BSLC6A2 | |
| SCHEMBL6431435 | 0.73 | BCL2A1 (0.46) | SLC6A2SLC6A4BCL2A1SLC6A3DRD2 | |
| SCHEMBL6431436 | 0.73 | BCL2A1 (0.46) | SLC6A2SLC6A4BCL2A1SLC6A3DRD2 | |
| SCHEMBL6466632 | 0.71 | HTR2A (0.40) | DYRK1AHTR2CHTR2ASLC6A2SLC6A4 | |
| SCHEMBL6466626 | 0.71 | HTR2A (0.40) | DYRK1AHTR2CHTR2ASLC6A2SLC6A4 | |
| SCHEMBL6464076 | 0.71 | HTR2A (0.40) | DYRK1AHTR2CHTR2ASLC6A2SLC6A4 | |
| SCHEMBL6464074 | 0.71 | HTR2A (0.40) | DYRK1AHTR2CHTR2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924289-B2 | Benzyl(Idene)-lactam derivatives, their preparation and their use as selective (ANT) agonists of 5-HT1A- and/or 5-HT1D receptors | PFIZER INC (US) | 2005-08-02 | — | — | US | disclosed |
| US-6462048-B2 | 3-(2-(4-METHYLPIPERAZIN-1-YL)-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE FOR EXAMPLE; USEFUL AS PSYCHOTHERAPEUTIC AGENTS | PFIZER INC. | 2002-10-08 | — | — | US | disclosed |
| EP-0894085-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER INC. (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1997036867-A1 | BENZYL(IDENE)-LACTAM DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE (ANT)AGONISTS OF 5-HT1A- AND/OR 5-HT1D RECEPTORS | PFIZER INC. (US) | 1997-10-09 | — | — | WO | disclosed |