SCHEMBL6464374

SCHEMBL6464374

CCCCC1CC[C@@H]2C[C@H](c3cc(F)c(-c4ccc(F)c(F)c4)c(F)c3)CC[C@@H]2C1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.34
ESR2 Q92731 1/20 0.31
KDM1A O60341 1/20 0.30
MAOB P27338 1/20 0.30
PDE5A O76074 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6464380 1.00 GCGR (0.34) GCGRESR2KDM1AMAOBPDE5A
SCHEMBL6452003 0.97 GCGR (0.36) GCGRPDE5A
SCHEMBL6451998 0.97 GCGR (0.36) GCGRPDE5A
SCHEMBL6462327 0.96 GCGR (0.35) GCGRPDE5A
SCHEMBL6452044 0.96 GCGR (0.35) GCGRPDE5A
SCHEMBL6452045 0.96 GCGR (0.35) GCGRPDE5A
SCHEMBL6462322 0.96 GCGR (0.35) GCGRPDE5A
SCHEMBL6460511 0.93 CYP2C9 (0.32) GCGR
SCHEMBL6460516 0.93 CYP2C9 (0.32) GCGR
SCHEMBL6451405 0.90 PTGS1 (0.35) GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6913797-B1 Decahydronaphthalene derivative DAINIPPON INK AND CHEMICALS, INC. (JP) 2005-07-05 US disclosed
EP-1108700-A1 DECAHYDRONAPHTHALENE DERIVATIVE DAINIPPON INK AND CHEMICALS, INC. (JP) 2001-06-20 EP disclosed