Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | FPR2 | P25090 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987238 | 0.82 | CDK2 (0.75) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL3787099 | 0.82 | CDK2 (0.75) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL6873118 | 0.81 | EPHX1 (0.58) | FPR2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL30831950 | 0.81 | CDK2 (0.73) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL17524348 | 0.81 | CDK2 (0.73) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL28030360 | 0.80 | SMN1; SMN2 (0.67) | L3MBTL1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3780409 | 0.79 | FLT4 (0.81) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL12989334 | 0.79 | CDK2 (0.81) | CDK2FLT4L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL28253513 | 0.79 | HDAC3 (0.76) | CDK2FLT4L3MBTL1MEN1KMT2A | |
| SCHEMBL30051982 | 0.79 | MEN1 (0.77) | CDK2FLT4L3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |