Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	LCK	P06239	7/20	0.69

▸	SRC	P12931	7/20	0.69

▸	TEK	Q02763	7/20	0.69

▸	KDR	P35968	4/20	0.69

▸	EGFR	P00533	2/20	0.69

▸	FYN	P06241	2/20	0.69

▸	LYN	P07948	2/20	0.69

▸	CSK	P41240	2/20	0.69

▸	BTK	Q06187	2/20	0.69

▸	KDM4E	B2RXH2	1/20	0.69

▸	MEN1	O00255	1/20	0.69

▸	RGS12	O14924	1/20	0.69

▸	NPC1	O15118	1/20	0.69

▸	GMNN	O75496	1/20	0.69

▸	ALDH1A1	P00352	1/20	0.69

▸	LMNA	P02545	1/20	0.69

▸	TP53	P04637	1/20	0.69

▸	CYP1A2	P05177	1/20	0.69

▸	CYP3A4	P08684	1/20	0.69

▸	CYP2D6	P10635	1/20	0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL6464807	1.00	LCK (0.69)	LCKSRCTEKKDREGFR
Acetic Acid SCHEMBL6866051	0.94	LCK (0.68)	LCKSRCTEKKDREGFR
Acetic Acid SCHEMBL6465904	0.94	LCK (0.68)	LCKSRCTEKKDREGFR
Acetic Acid SCHEMBL6465909	0.94	LCK (0.68)	LCKSRCTEKKDREGFR
SCHEMBL6464809	0.91	LCK (0.66)	LCKSRCTEKKDREGFR
SCHEMBL23834504	0.90	HCK (0.70)	LCKSRCTEKKDREGFR
SCHEMBL30143838	0.90	HCK (0.70)	LCKSRCTEKKDREGFR
SCHEMBL30053994	0.90	HCK (0.71)	LCKSRCTEKKDREGFR
SCHEMBL23834451	0.90	HCK (0.71)	LCKSRCTEKKDREGFR
SCHEMBL23834585	0.89	HCK (0.66)	LCKSRCTEKKDREGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20050008640-A1	Method of treating transplant rejection	ABBOTT LABORATORIES	2005-01-13	—	—	US	disclosed
US-6713474-B2	SERINE-THREONINE AND TYROSINE KINASE INHIBITORS	ABBOTT GMBH & CO. KG (DE)	2004-03-30	—	—	US	disclosed
US-20030153752-A1	Pyrrolopyrimidines as therapeutic agents	ABBVIE DEUTSCHLAND GMBH & CO KG (DE)	2003-08-14	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20050008640-A1	Method of treating transplant rejection	LCK, ZAP70, FYN	LCK 1/4885SRC 46/4885TEK 1465/4885
US-20030153752-A1	Pyrrolopyrimidines as therapeutic agents	FLT1, FLT4, TFPI	LCK 6/4885SRC 206/4885TEK 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.