Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6465932 | 0.88 | USP2 (0.40) | SMN1; SMN2USP2NR1H2HTRA1RECQL | |
| SCHEMBL1021180 | 0.88 | USP2 (0.40) | SMN1; SMN2USP2NR1H2HTRA1RECQL | |
| SCHEMBL23458178 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL31716576 | 0.83 | PTPN1 (0.41) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL8892617 | 0.83 | PTPN1 (0.41) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL1024057 | 0.83 | HSD17B10 (0.43) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL6448272 | 0.83 | HSD17B10 (0.43) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL17031907 | 0.83 | USP2 (0.41) | SMN1; SMN2USP2NR1H2RECQLHSD17B10 | |
| SCHEMBL23458177 | 0.77 | SPHK1 (0.37) | SMN1; SMN2USP2NR1H2HTRA1HSD17B10 | |
| SCHEMBL23458190 | 0.76 | HSD17B10 (0.46) | SMN1; SMN2NR1H2HSD17B10CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |