Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.52 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646377 | 0.94 | HSP90AA1 (0.47) | HSP90AA1RORCKEAP1NFE2L2HSP90AB1 | |
| SCHEMBL644848 | 0.94 | HSP90AA1 (0.52) | HSP90AA1RORCKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL645274 | 0.93 | HSP90AA1 (0.49) | HSP90AA1RORCKEAP1NFE2L2ALDH1A1 | |
| SCHEMBL646699 | 0.92 | HSP90AA1 (0.49) | HSP90AA1KEAP1NFE2L2HSP90AB1ALDH1A1 | |
| SCHEMBL646966 | 0.90 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1LMNAPOLB | |
| SCHEMBL4933407 | 0.89 | HSP90AA1 (0.55) | HSP90AA1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL644577 | 0.89 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL646667 | 0.89 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1ALDH1A1LMNAPOLB | |
| SCHEMBL644660 | 0.89 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1ALDH1A1LMNAPOLB | |
| SCHEMBL645309 | 0.88 | HSP90AA1 (0.47) | HSP90AA1KEAP1NFE2L2HSP90AB1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | claimed |
| US-8119795-B2 | Triazole derivatives II | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | claimed |
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-28 | — | — | US | claimed |
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885RORC 749/4885KEAP1 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.