Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6467968 | 0.93 | KDR (0.41) | KDRMEN1KMT2AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL6467347 | 0.89 | FGFR2 (0.38) | KDREGFRMEN1KMT2AALDH1A1 | |
| SCHEMBL6469351 | 0.88 | MEN1 (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL6469301 | 0.88 | KDR (0.37) | KDRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6470577 | 0.88 | NPSR1 (0.43) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL6467438 | 0.86 | FGFR2 (0.41) | EGFRMEN1KMT2AALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL6469711 | 0.84 | RET (0.39) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL6469542 | 0.84 | NPSR1 (0.55) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL6470340 | 0.84 | BRAF (0.41) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL6467974 | 0.83 | KDR (0.38) | KDREGFRMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030131-A2 | BIS-QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | REPLIDYNE, INC (US) | 2005-04-07 | — | — | WO | disclosed |