Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1A | P50416 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | NAA50 | Q9GZZ1 | 2/20 | 0.34 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3512866 | 0.94 | TSHR (0.38) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL2317005 | 0.94 | TSHR (0.38) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL6466568 | 0.92 | TSHR (0.40) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL166241 | 0.88 | TRPV1 (0.42) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL166240 | 0.88 | TRPV1 (0.42) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL6466955 | 0.88 | BAZ2A (0.41) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL6464489 | 0.87 | POLB (0.39) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL3514481 | 0.86 | TSHR (0.38) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL6467500 | 0.86 | RHOA (0.41) | TSHRTRPV1POLBHSP90AA1HSP90AB1 | |
| SCHEMBL3514484 | 0.86 | TSHR (0.38) | TSHRTRPV1POLBHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |