SCHEMBL6469830

SCHEMBL6469830

COC(=O)/C(O)=C/C(=O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.58
NR4A1 P22736 1/20 0.57
NR4A2 P43354 1/20 0.57
NR4A3 Q92570 1/20 0.57
PPARG P37231 3/20 0.56
PARP10 Q53GL7 1/20 0.55
ABCG2 Q9UNQ0 1/20 0.54
SRD5A2 P31213 1/20 0.54
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CASP3 P42574 1/20 0.52
SENP8 Q96LD8 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
SENP6 Q9GZR1 1/20 0.52
GPR55 Q9Y2T6 1/20 0.52
HDAC3 O15379 1/20 0.52
HDAC1 Q13547 1/20 0.52
HDAC2 Q92769 1/20 0.52
NCOR2 Q9Y618 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6031200 1.00 MAOB (0.58) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL1131974 0.87 NR1H4 (0.62) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL1131978 0.87 NR1H4 (0.62) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL3888880 0.86 NR4A1 (0.64) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL3888890 0.86 NR4A1 (0.64) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL3888888 0.86 NR4A1 (0.64) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL6029653 0.86 MAOB (0.55) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL6029648 0.86 MAOB (0.55) MAOBNR4A1NR4A2NR4A3PPARG
SCHEMBL5870890 0.83 MAOB (0.54) MAOBPARP10ABCG2NPC1RAB9A
SCHEMBL9043616 0.81 MAOB (0.67) MAOBNR4A1NR4A2NR4A3PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1594846-A1 BIS(HETERO)ARYL CARBOXAMIDE DERIVATIVES FOR USE AS PGI2 ANTAGONISTS Bayer HealthCare AG (DE) 2005-11-16 EP disclosed
WO-2004069805-A1 BIS(HETERO)ARYL CARBOXAMIDE DERIVATIVES FOR USE AS PGI2 ANTAGONISTS BAYER HEALTHCARE AG (DE) 2004-08-19 WO disclosed