Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 8/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884756 | 0.95 | AURKA (0.58) | AURKAAURKBKDRHDAC3HDAC4 | |
| SCHEMBL5045117 | 0.95 | AURKA (0.55) | AURKAAURKBKDRHDAC3HDAC4 | |
| SCHEMBL6470602 | 0.95 | AURKA (0.64) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL6471691 | 0.93 | AURKA (0.60) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5049618 | 0.92 | AURKA (0.66) | AURKAAURKBKDRHDAC3HDAC4 | |
| SCHEMBL5045615 | 0.91 | AURKA (0.64) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5049559 | 0.90 | AURKA (0.61) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3888253 | 0.89 | AURKA (0.59) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5049886 | 0.88 | AURKA (0.56) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL6470103 | 0.87 | AURKA (0.66) | AURKAAURKBKDRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |