Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | CSK | P41240 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889012 | 0.96 | AURKA (0.69) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5048953 | 0.96 | AURKA (0.66) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5046330 | 0.93 | AURKA (0.73) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL3883357 | 0.91 | AURKA (0.70) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL4048938 | 0.90 | AURKA (0.75) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5046243 | 0.89 | AURKA (0.71) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5042162 | 0.88 | AURKA (0.83) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5045809 | 0.87 | AURKA (0.79) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL5045762 | 0.87 | AURKA (0.70) | AURKAAURKBEGFRFGFR1KDR | |
| SCHEMBL3892716 | 0.87 | AURKA (0.70) | AURKAAURKBEGFRFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |