SCHEMBL6470762

SCHEMBL6470762

c1ccc(Cc2ccc(-c3cc4ccccc4o3)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.62
MMP12 P39900 1/20 0.56
MMP13 P45452 1/20 0.56
ALOX5 P09917 1/20 0.54
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
CA9 Q16790 1/20 0.54
S1PR1 P21453 1/20 0.52
BCHE P06276 4/20 0.50
CNR1 P21554 1/20 0.50
ACHE P22303 1/20 0.50
MAOA P21397 1/20 0.50
P2RY14 Q15391 1/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
NPC1 O15118 1/20 0.50
ALDH1A1 P00352 1/20 0.50
NFKB1 P19838 1/20 0.50
NPY1R P25929 1/20 0.50
RAB9A P51151 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5768216 0.83 MAOB (0.72) MAOBMMP12MMP13ALOX5CA1
SCHEMBL4659168 0.83 MAOB (0.78) MAOBMMP12MMP13ALOX5CA1
SCHEMBL31105656 0.83 MAOB (0.71) MAOBALOX5CA1CA2CA9
SCHEMBL731363 0.83 MAOB (0.71) MAOBALOX5CA1CA2CA9
SCHEMBL30142393 0.83 MAOB (0.62) MAOBMMP12MMP13ALOX5CA1
SCHEMBL30142395 0.83 MAOB (0.67) MAOBMMP12MMP13ALOX5CA1
SCHEMBL4909820 0.83 MAOB (0.62) MAOBMMP12MMP13ALOX5CA1
SCHEMBL4901769 0.83 MAOB (0.62) MAOBMMP12MMP13ALOX5CA1
SCHEMBL2056341 0.83 MAOB (0.62) MAOBMMP12MMP13ALOX5CA1
SCHEMBL28209117 0.83 MAOB (0.62) MAOBMMP12MMP13ALOX5CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005049593-A2 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ABBOTT LABORATORIES (US) 2005-06-02 WO disclosed