Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1201488 | 0.90 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL1202987 | 0.84 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL2081481 | 0.83 | PTPN1 (0.47) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL21490343 | 0.80 | PTPN1 (0.65) | PTPN1NR1H2NR1H3HDAC8 | |
| SCHEMBL2737917 | 0.80 | PTPN1 (0.65) | PTPN1NR1H2NR1H3HDAC8 | |
| SCHEMBL29443079 | 0.80 | PTPN1 (0.65) | PTPN1NR1H2NR1H3HDAC8 | |
| SCHEMBL21881601 | 0.77 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL3697808 | 0.77 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL20483181 | 0.76 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 | |
| SCHEMBL16271289 | 0.76 | PTPN1 (0.53) | PTPN1NR1H2NR1H3HDAC8UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153998-A1 | Tetrahydroisoquinoline or isochroman compounds | ITO FUMITAKA (JP) | 2005-07-14 | — | — | US | disclosed |
| WO-2005049602-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005016913-A1 | TETRAHYDROISOQUINOLINE OR ISOCHROMAN COMPOUNDS AS ORL-1 RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN AND CNS DISORDERS | PFIZER JAPAN, INC. (JP) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153998-A1 | Tetrahydroisoquinoline or isochroman compounds | OPRL1, NR1H3, HRH3 | PTPN1 2698/4885NR1H2 6/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.