Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109888 | 0.93 | TDP1 (0.46) | TDP1DPP4L3MBTL1CCKBRKDM4E | |
| SCHEMBL14177368 | 0.89 | TDP1 (0.49) | TDP1L3MBTL1HRH4HRH3S1PR1 | |
| SCHEMBL5100339 | 0.88 | TDP1 (0.47) | TDP1L3MBTL1HRH4HRH3KDM4E | |
| SCHEMBL5097259 | 0.85 | TDP1 (0.43) | TDP1DPP4L3MBTL1HRH4HRH3 | |
| SCHEMBL5096980 | 0.82 | TDP1 (0.49) | TDP1L3MBTL1HRH4HRH3KDM4E | |
| SCHEMBL5104124 | 0.81 | TDP1 (0.48) | TDP1L3MBTL1HRH4HRH3KDM4E | |
| SCHEMBL5110461 | 0.80 | TDP1 (0.47) | TDP1L3MBTL1HRH4HRH3KDM4E | |
| SCHEMBL5100728 | 0.80 | TDP1 (0.49) | TDP1L3MBTL1HRH4HRH3KDM4E | |
| SCHEMBL5103717 | 0.80 | TDP1 (0.47) | TDP1L3MBTL1S1PR1S1PR3KDM4E | |
| SCHEMBL5100953 | 0.80 | TDP1 (0.49) | TDP1L3MBTL1HRH4HRH3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575925-A1 | NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004056784-A1 | NOVEL CARBOXAMIDES, THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-08 | — | — | WO | disclosed |