Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473202 | 0.94 | MAPK14 (0.49) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471751 | 0.92 | MAPK14 (0.55) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471517 | 0.92 | MAPK14 (0.51) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471677 | 0.91 | MAPK14 (0.46) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471285 | 0.91 | MAPK14 (0.55) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6474194 | 0.91 | MAPK14 (0.49) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471760 | 0.90 | MAPK14 (0.53) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6474423 | 0.90 | MAPK14 (0.44) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6474664 | 0.90 | MAPK14 (0.49) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL4386716 | 0.90 | MAPK14 (0.56) | MAPK14ROCK2MAPK12MAPK11STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216754-A1 | USE OF P38 MAPK INHIBITORS FOR PREVENTION AND TREATMENT OF AGING AND AGING-RELATED DISORDERS AND FOR BOOSTING AN IMMUNE SYSTEM | Spring Discovery, Inc. (US) | 2021-10-28 | — | — | WO | disclosed |
| EP-3429603-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION | Children's Medical Center Corporation (US) | 2019-01-23 | — | — | EP | disclosed |
| EP-3313420-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | Children's Medical Center Corporation (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2017161001-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2016210292-A1 | METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2016-12-29 | — | — | WO | disclosed |
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |