SCHEMBL6471920

SCHEMBL6471920

Cc1[nH]c(=O)c(Br)c(OCc2ccc(F)cc2F)c1-c1cc(C(C)(C)O)cc(C(C)(C)O)c1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 18/20 0.40
MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6474304 0.83 PTGER1 (0.43) MAPK14MAOB
SCHEMBL6471953 0.82 MAPK14 (0.41) MAPK14
SCHEMBL6471786 0.82 MAPK14 (0.39) MAPK14
SCHEMBL6472799 0.82 MAOB (0.44) MAPK14MAOB
SCHEMBL6472056 0.81 MAPK14 (0.47) MAPK14
SCHEMBL6471353 0.81 MAPK14 (0.54) MAPK14MAOB
SCHEMBL6475003 0.80 MAPK14 (0.52) MAPK14
SCHEMBL6473814 0.80 MAPK14 (0.43) MAPK14
SCHEMBL6475153 0.79 MAPK14 (0.55) MAPK14MAOB
SCHEMBL6471547 0.79 PTGER1 (0.49) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005018557-A2 SUBSTITUTED PYRIDINONES PHARMACIA CORPORATION (US) 2005-03-03 WO disclosed