Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6471475 | 0.89 | MAPK14 (0.41) | MMP1IKBKBCHUKMAPK14PTGS1 | |
| SCHEMBL6473270 | 0.85 | PTGS1 (0.42) | MAPK14PTGS1PTGS2 | |
| SCHEMBL6533872 | 0.85 | MAPK14 (0.44) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471115 | 0.83 | MAPK14 (0.41) | MAPK14PTGS1PTGS2 | |
| SCHEMBL6471141 | 0.82 | MAPK14 (0.39) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6473656 | 0.81 | MAPK14 (0.47) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471706 | 0.80 | MAPK14 (0.45) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6471870 | 0.80 | MAPK14 (0.41) | MAPK14ALDH1A1 | |
| SCHEMBL6472713 | 0.80 | MAPK14 (0.55) | MAPK14ROCK2MAPK12MAPK11STRADA | |
| SCHEMBL6472007 | 0.79 | MAPK14 (0.48) | MAPK14ROCK2MAPK12MAPK11STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |