Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL644634 | 0.92 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TSHRALDH1A1CYP2C19 | |
| SCHEMBL646593 | 0.92 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1TSHRALDH1A1MEN1 | |
| SCHEMBL645477 | 0.91 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1TSHRPOLBHPGD | |
| SCHEMBL645183 | 0.91 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1TSHRHPGDNPSR1 | |
| SCHEMBL644870 | 0.90 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1TSHRALDH1A1POLB | |
| SCHEMBL646874 | 0.89 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1TSHRALDH1A1MEN1 | |
| SCHEMBL645397 | 0.89 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1TSHRALDH1A1TDP1 | |
| SCHEMBL644858 | 0.89 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1TSHRALDH1A1CYP3A4 | |
| SCHEMBL646606 | 0.88 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL645569 | 0.88 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023922-B1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GMBH (DE) | 2012-07-11 | — | — | EP | claimed |
| US-8119795-B2 | Triazole derivatives II | MERCK PATENT GMBH (DE) | 2012-02-21 | — | — | US | claimed |
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | MERCK PATENT GESELLSCHAFT (DE) | 2010-01-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022540-A1 | TRIAZOLE DERIVATIVES II | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885TSHR 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.