SCHEMBL6473372

SCHEMBL6473372

O=c1cc([Si](c2cc[nH]c(=O)c2)(c2cc[nH]c(=O)c2)c2cc[nH]c(=O)c2)cc[nH]1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.45
FKBP5 Q13451 1/20 0.39
CRBN Q96SW2 1/20 0.37
NSD2 O96028 1/20 0.36
ABL1 P00519 1/20 0.36
PPARG P37231 1/20 0.36
RIN1 Q13671 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
HDAC6 Q9UBN7 2/20 0.36
TP53 P04637 1/20 0.34
MAP4K4 O95819 2/20 0.33
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
JAK2 O60674 1/20 0.33
JAK1 P23458 1/20 0.33
TYK2 P29597 1/20 0.33
KMT2A Q03164 2/20 0.31
MAPT P10636 1/20 0.31
MEN1 O00255 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6042142 0.70 NOTUM (0.77) NOTUMFKBP5CRBNNSD2ABL1
SCHEMBL9199411 0.69
SCHEMBL9314832 0.67
SCHEMBL165148 0.67
SCHEMBL259457 0.67
SCHEMBL23986400 0.67
SCHEMBL608199 0.67
SCHEMBL13071189 0.67
SCHEMBL1521838 0.67
SCHEMBL222661 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6972304-B2 Aqueous ink compositions XEROX CORPORATION (US) 2005-12-06 US disclosed
US-6906118-B2 Phase change ink compositions XEROX CORPORATION (US) 2005-06-14 US disclosed
US-20030105185-A1 Phase change ink compositions XEROX CORPORATION 2003-06-05 US disclosed
US-20030079644-A1 Aqueous ink compositions XEROX CORPORATION 2003-05-01 US disclosed