⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946914 | 0.82 | — | — | |
| SCHEMBL19359134 | 0.74 | — | — | |
| SCHEMBL3990750 | 0.71 | CA1 (0.36) | — | |
| SCHEMBL433283 | 0.70 | — | — | |
| SCHEMBL577436 | 0.69 | — | — | |
| SCHEMBL20658834 | 0.67 | — | — | |
| SCHEMBL17993586 | 0.67 | — | — | |
| SCHEMBL20604088 | 0.65 | — | — | |
| SCHEMBL13507066 | 0.65 | — | — | |
| SCHEMBL20550461 | 0.64 | CA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409617-A2 | Thiolactams, process for their preparation and use as biocides | ZENECA LIMITED (GB) | 1991-01-23 | — | — | EP | claimed |
| JP-3068553-A | — | — | None | — | — | JP | disclosed |
| WO-2012104538-A1 | NOVEL 1,5-DIHYDROPYRROL-2-ONE DERIVATIVES FOR USE IN THE TREATMENT OF MALARIA OR OTHER PARASITIC AND FUNGAL DISEASES | UNIVERSITE CLAUDE BERNARD LYON I (FR) | 2012-08-09 | — | — | WO | disclosed |
| US-6936633-B2 | Pyrrolidinone derivatives | UCB S.A. (BE) | 2005-08-30 | — | — | US | disclosed |
| US-6727275-B2 | ANTIINFLAMMATORY, ANTIALLERGEN, AND ANTIASTHMATIC AGENTS | UCB, S.A./N.V. (BE) | 2004-04-27 | — | — | US | disclosed |
| EP-0409617-B1 | Process for the preparation of metal complexes of thiolactams | ZENECA LTD (GB) | 1998-11-11 | — | — | EP | disclosed |
| US-5506253-A | REACTING ACETOXYPYRROLIDINONE COMPOUND WITH METAL TRIALKYLSILANOLATE | ZENECA LIMITED (GB) | 1996-04-09 | — | — | US | disclosed |
| US-5393750-A | Biocides | ZENECA, LIMITED (GB) | 1995-02-28 | — | — | US | disclosed |
| US-5120856-A | Bactericides, fungicides, algicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-06-09 | — | — | US | disclosed |
| JP-H0368553-A | PRODUCTION AND APPLICATION OF COMPOSITION OF BIOCIDE | IMPERIAL CHEM IND PLC <ICI> | 1991-03-25 | — | — | JP | disclosed |
| EP-0409617-A2 | Thiolactams, process for their preparation and use as biocides | ZENECA LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |