SCHEMBL647372

SCHEMBL647372

COC(=O)c1ccccc1N(C)S(C)(=O)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 1.00
L3MBTL1 Q9Y468 4/20 0.67
TSHR P16473 3/20 0.57
NPSR1 Q6W5P4 2/20 0.55
GAA P10253 2/20 0.54
ALDH1A1 P00352 2/20 0.53
POLB P06746 1/20 0.53
MEN1 O00255 1/20 0.51
HSD17B10 Q99714 1/20 0.51
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA5A P35218 1/20 0.50
CA9 Q16790 1/20 0.50
USP2 O75604 1/20 0.50
MAPT P10636 1/20 0.49
HTT P42858 1/20 0.49
LMNA P02545 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27468102 0.85 KMT2A (0.74) KMT2AL3MBTL1TSHRNPSR1ALDH1A1
SCHEMBL27468103 0.85 KMT2A (0.74) KMT2AL3MBTL1TSHRNPSR1GAA
SCHEMBL25221412 0.83 GAA (0.76) KMT2AL3MBTL1NPSR1GAAALDH1A1
SCHEMBL2634637 0.83 KMT2A (0.70) KMT2AL3MBTL1TSHRNPSR1GAA
SCHEMBL7686887 0.82 KMT2A (0.69) KMT2AL3MBTL1TSHRNPSR1GAA
SCHEMBL222373 0.81 KMT2A (0.68) KMT2AL3MBTL1TSHRNPSR1ALDH1A1
SCHEMBL30005605 0.81 KMT2A (0.68) KMT2AL3MBTL1TSHRNPSR1ALDH1A1
SCHEMBL9624386 0.81 KMT2A (0.68) KMT2AL3MBTL1TSHRNPSR1ALDH1A1
SCHEMBL4444645 0.80 KMT2A (0.67) KMT2AL3MBTL1TSHRNPSR1GAA
SCHEMBL29408467 0.80 KMT2A (0.67) KMT2AL3MBTL1TSHRNPSR1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230183394-A1 CATALYST FOR PROPYLENE POLYMERIZATION, CATALYST SYSTEM FOR PROPYLENE POLYMERIZATION, AND PREPARATION AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2023-06-15 US claimed
CN-113621098-B Propylene polymerization catalyst, propylene polymerization catalyst system, preparation and application thereof 中国石油天然气股份有限公司 2022-11-04 CN claimed
CN-113621098-A Propylene polymerization catalyst, propylene polymerization catalyst system, preparation and application thereof 中国石油天然气股份有限公司 2021-11-09 CN claimed
WO-2025085848-A1 ANTIBACTERIAL COMPOUNDS ARREPATH, INC. (US) 2025-04-24 WO disclosed
WO-2025054132-A1 ANTIBACTERIAL COMPOUNDS ARREPATH, INC. (US) 2025-03-13 WO disclosed
US-20230183394-A1 CATALYST FOR PROPYLENE POLYMERIZATION, CATALYST SYSTEM FOR PROPYLENE POLYMERIZATION, AND PREPARATION AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2023-06-15 US disclosed
US-20230183394-A1 CATALYST FOR PROPYLENE POLYMERIZATION, CATALYST SYSTEM FOR PROPYLENE POLYMERIZATION, AND PREPARATION AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2023-06-15 US disclosed
US-20230183394-A1 CATALYST FOR PROPYLENE POLYMERIZATION, CATALYST SYSTEM FOR PROPYLENE POLYMERIZATION, AND PREPARATION AND USE THEREOF PETROCHINA COMPANY LIMITED (CN) 2023-06-15 US disclosed
CN-113621098-B Propylene polymerization catalyst, propylene polymerization catalyst system, preparation and application thereof 中国石油天然气股份有限公司 2022-11-04 CN disclosed
WO-2022220725-A1 LPXH INHIBITORS AS ANTI-INFECTIVE AGENTS ZAMARATSKI EDOUARD (SE) 2022-10-20 WO disclosed
CN-113621098-A Propylene polymerization catalyst, propylene polymerization catalyst system, preparation and application thereof 中国石油天然气股份有限公司 2021-11-09 CN disclosed
US-8119666-B2 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase) NOVARTIS AG (CH) 2012-02-21 US disclosed
US-20080293776-A1 1,2,5-Thiazolidine Derivatives Useful for Treating Conditions Mediated by Protein Tyrosine Phosphatases (Ptpase) NOVARTIS AG (CH) 2008-11-27 US disclosed
EP-1963294-A1 1,2,5-THIAZOLIDINE DERIVATIVES USEFUL FOR TREATING CONDITIONS MEDIATED BY PROTEIN TYROSINE PHOSPHATASES (PTPASE) Novartis AG (CH) 2008-09-03 EP disclosed
WO-2007067613-A1 1,2,5-THIAZOLIDINE DERIVATIVES USEFUL FOR TREATING CONDITIONS MEDIATED BY PROTEIN TYROSINE PHOSPHATASES (PTPASE) NOVARTIS AG (CH) 2007-06-14 WO disclosed
US-20020045551-A1 4-benzoyl isoxazoles derivatives and their use as herbicides MUSIL TIBOR (GB) 2002-04-18 US disclosed
US-6323155-B1 EXCELLENT LEVEL OF HERBICIDAL ACTIVITY TOGETHER WITH CROP TOLERANCE RHONE-POULENC AGRICULTURE LIMITED (GB) 2001-11-27 US disclosed
EP-0674629-B1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE (GB) 1998-07-08 EP disclosed
EP-0674629-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-10-04 EP disclosed
WO-1994014782-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1994-07-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293776-A1 1,2,5-Thiazolidine Derivatives Useful for Treating Conditions Mediated by Protein Tyrosine Phosphatases (Ptpase) PTPRS, PTPN5, PTPRR KMT2A 2549/4885L3MBTL1 2780/4885TSHR 714/4885
US-20020045551-A1 4-benzoyl isoxazoles derivatives and their use as herbicides CBR3, CBR1, GLRA3 KMT2A 3499/4885L3MBTL1 2099/4885TSHR 174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.